Spot Reduction Revisited: Removing Stubborn Thigh Fat


Is it possible to remove fat from specific areas of the body? (Photo of low-fat legs: Kirikiri)

(Preface: This is one of the “bonus chapters” for The 4-Hour Body. My sincerest apologies for the confusion! All bonus materials can be found here. Enjoy! New forums and more coming very soon…)

I’m allergic to food. Every time I eat it breaks out into fat.
—Jennifer Greene Duncan

Does History record any case in which the majority was right?
—Robert Heinlein

In the early 1900s, a 12-year-old girl burned the back of her hand. You are right: this is not newsworthy.

It’s what followed the burn, documented in the medical records, that fascinated me:

Doctors used skin from her abdomen as a graft over the burn. By the time this girl turned thirty, she had grown fat, and the skin that had been transplanted to the back of her hand had grown fat as well. “A second operation was necessary for the removal of the big fat pads which had developed in the grafted skin,” explained the University of Vienna endocrinologist and geneticist Julius Bauer, “exactly as fatty tissue had developed in the skin of the lower part of the abdomen.”

The plight of women and fat is the stuff of legend.

Female fat deposition in the legs and buttocks increases with age, as does abdominal fat and the so-called saddle bags—fat just beneath the hips—in perimenopausal and menopausal women.

How is it that women can eat peanut butter, for example, and seemingly bypass the stomach to put it directly on their asses? Why doesn’t this happen to men, who seem to put fat directly on their would-be six-pack, which ends up resembling more of a one-pack (or “six-pack in the cooler”), even if they have bodybuilder-like veins on their arms?

To paraphrase Gary Taubes: some biological factor must regulate this. One candidate is the A-2 receptor, and that is what I decided to look at for practical experimentation…

The A-2 receptor, or alpha-2 andrenergic receptor, is the party spoiler when it comes to fat-loss in gender-specific problem areas. From the journal Obesity Research (bolding is mine):

The fat on women’s thighs is more difficult to mobilize due to increased alpha-2 adrenergic receptor activity induced by estrogen. Lipolysis [fat-loss] can be initiated through adipocyte receptor stimulation (beta adrenergic) or inhibition (adenosine or alpha-2 adrenergic) or by inhibition of phosphodiesterase.

In plain Ingrish, this means that estrogen helps pesky fat-mongering A-2 receptors do their work, and there are three effective gambits for losing fat despite this.

For decades, the consensus among exercise professionals has been that spot reduction—reducing fat in one specific body area—is impossible, a myth. I long assumed this was the case until I asked the hypothetical question: if we assume there might be an effective mechanism for spot reduction, what would it look like if we focused on the three above pathways?

It seemed that one answer would be a topical lotion that inhibits the A-2 receptor or blocks phosphodiesterase (1). Another potent and supporting mechanism might be reducing the availability of cortisol at the level of the fat cells themselves (2).

Guess what? There are compounds that can be used for either: aminophylline for the former and glycyrrhetinic acid for the latter.

The two are quite different. Aminophylline is a bronchodilator used for asthma that contains theophylline, a stimulant found in tea that is similar to caffeine. Glycyrrhetinic acid, on the other hand, prevents the breakdown of specific prostaglandins (PGE-2 and PGF-2a) and is derived from licorice; it can be used as a base for expectorants or even artificial sweeteners.

Fat-loss is an off-label use for the latter in particular, but clinical studies indicate that both can selectively reduce thigh fat in females and males when applied as a cream.

During the process of researching this book, I saw firsthand the empirical evidence of spot reduction with low-dose, high-frequency injections of human growth hormone (HGH), but the potential legal ramifications and side effects (like bone and organ growth) make HGH unattractive. If you see bodybuilders with distended abdomens that make them look like they’re nine months pregnant, you’ve probably seen drug-induced visceral organ growth. It’s not a look I recommend.

I’d also experimented on three occasions with converting yohimbine HCL into a topical cream based on the writing of Dan Duchaine, but the side effects, including excessive salivation (thank you, autonomous nervous system), weren’t worth the negligible fat-loss.

Feeling like a Pavlovian dog about to vomit is no way to spend your life, and abs won’t help your sex appeal if you’re drooling on yourself.

It Rubs the Lotion on Its Skin

I took a nine-year hiatus from experimenting with spot reduction, until The 4-Hour Body gave me the excuse to fuss with it again.

The research led me to aminophylline and glycyrrhetinic acid. All that remained was to get my hands on both, which I did.

The easiest-to-purchase source of a 2% aminophylline cream was the extremely scammy-sounding Celluthin™, which I ordered on Amazon.

Glycyrrhetinic acid was much harder to locate, as I could only find it through prescription as Atopiclair™, which is used for dermatitis and has a single U.S. distributor in Tennessee, Graceway Pharmaceuticals LLC. Even with prescription-writing doctors willing to indulge me, Graceway made it almost impossible to find the product details and prescribing information for dosing. The latter is needed to write a “script,” of course. Eventually we ferreted it out of some subpage on the website, and I was able to fill candidate B at a local Walgreen’s within 48 hours.

Celluthin cost $49.99, and Atopiclair topped out at more than $100.

Here’s what happened. We’ll look at the prescription drug first, for reasons that will become clear.

The Results

Glycyrrhetinic Acid Cream (Atopiclair®)

FIRST, A WARNING FOR WOMEN: Glycyrrhetinic acid inhibits the breakdown of several prostaglandins, including PGF-2a, which therefore increases their levels. Since PGF-2a is known to stimulate uterine activity during pregnancy and can cause miscarriage, glycyrrhetinic acid should not be taken by those who are pregnant or attempting to become pregnant.

I applied Atopiclair thrice daily—upon waking, again at 5:00 P.M., and again before bed—for 13 days. I believe both the effects and potential side effects would have been even more pronounced for a woman:

Before (November 10, 2009) and After (November 23, 2009)
Treated right chest: 5 mm –> 4.43 mm (-.57 mm)
Untreated left chest: 5 mm –> 5.5 mm (+.5 mm)

All measurements were taken at least three times and then averaged. For example, the first “5mm” was derived from readings of 4.9, 5.0, and 5.1 millimeters. But back to our story…

To account for systemic changes, such as diet-induced fat loss or gain, and to create a control, I treated only the right side of my chest on the upper torso. Sites were as far apart as possible and therefore near the armpits.

I lost more than 10% total fat on the treated side and gained exactly 10% on the untreated side. These measurements were clear, and the fat gain on the untreated area made sense, as I was in an overfeeding phase.

The next set of measurements, however, were confusing.

Treated right abdominal: 7.0 mm –> 5.93 mm (-1.07 mm)
Untreated left abdominal: 6.3 mm –> 5.13 mm (-1.17 mm)

The abdominal area I measured is the mid-tier of the six-pack, the second “bump” up from the bottom in the rectus abdominus, or the first “bump” above the navel. I chose this area instead of the usual one inch to either side of the navel because it produced more consistent readings with the ultrasound device I used (4).

You read the data right: though I lost fat on both sides, I lost more fat on the untreated side. No matter how many times I repeated the measurements, that was the conclusion.


I have no explanation, other than a possible crossover effect from the topical application, as the measured areas were separated by no more than one inch. I knew this would be a risk—hence the decision to measure the opposing sides of the chest as well.

Can we reconcile the apparent benefit on the chest and the conflicting data from the abs? Not with this alone. There is really only one solution: repeat the test.

Fortunately, our other candidate gave much clearer results.

Aminophylline Cream

Celluthin™ has the following ingredients listed on the label in (assuming this was done as the FTC requires) descending order of volume:

Purified water, Aminophylline, Yerbe Matte, Coleus Forskohli Extract, Oil of Peppermint, Carbomer, Triethanslamide, Liposomes, Butylparaben, Isobutylparaben, Isopropylparaben, Phenoxyethanol, D & C Red #28

I was particularly impressed with the misspellings of both “yerba mate” and “coleus forskohlii.” Needless to say, I did not expect this product to have an effect, and I couldn’t find clinical support for topical spot reduction use of the ingredients besides aminophylline.

I used the product twice daily on my right thigh only, upon waking and before sleep, for 18 days.

Before (October 12, 2009) and After (October 30, 2009) Measurements:
Treated right thigh midline, six inches above kneecap upper limit: 8.1 mm –> 7.4 mm5 (-0.7)
Untreated left thigh (same measurement): 7.9 mm –> 7.8 mm6 (-0.1)

On the treatment thigh, I lost 8.64% of my fat thickness, as opposed to a 1.26% loss on the control leg. Even more incredible was the apparent persistence of effect after cessation of use.

Here are the same measurements 11 days after I stopped application of the cream:
Right thigh: 7 mm (additional 5.71% reduction, or 0.4 mm)
Left thigh: 8.3 mm (a gain of 0.3 mm)

In other words, even though I was in an overeating phase and gained fat on my left thigh (0.3 millimeters), I continued to lose fat, almost an additional 6%, on the right thigh, which had been previously treated. I didn’t believe this outcome and remeasured the sites three times, but the data were consistent.

Consider me a believer.

Based on my experience, using a 2% aminophylline cream for two and a half weeks, applied twice daily, accelerates thigh fat-loss more than 10 times compared to a control.

I’ll leave the Atopiclair to the dermatitis sufferers.

Tools and Tricks

Celluthin – The topical lotion containing aminophylline that effectively inhibits the A-2 receptor. Use carefully, as it appears to continue to inhibit this receptor for at least several days after you’ve stopped using it.
Non-affiliate Amazon link
Affiliate Amazon link (I get a small commission)

Atopiclair (Glycyrrhetinic Acid Cream) ( Here’s where you can find more information about Atopiclair. You won’t be able to order the product directly, but you can get rebates on the official site if you decide to apply for a prescription.

Footnotes and References:

1 – This increases cAMP, which facilitates catecholamine stimulation of lipolysis.
2 – Via inhibition of 11beta-hydroxysteroid dehydrogenase type 1.
3 – All measurements were taken at least three times and averaged, in this case from
readings of 4.9, 5.0, and 5.1 millimeters.
4 – Using ultrasound higher than the standard abdominal point, the ultrasound echo
from the fascia (connective tissue) layer can get weaker, which reduces the risk of
the software switching between the fascia and the true fat-muscle interface.
5 – Averaged from measurements of 7.0, 7.3, 7.4, and 7.5 millimeters.
6 – Averaged from measurements of 8.0, 7.8, and 7.8 millimeters.

Posted on: January 16, 2011.

Watch The Tim Ferriss Experiment, the new #1-rated TV show with "the world's best human guinea pig" (Newsweek), Tim Ferriss. It's Mythbusters meets Jackass. Shot and edited by the Emmy-award winning team behind Anthony Bourdain's No Reservations and Parts Unknown. Here's the trailer.

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496 comments on “Spot Reduction Revisited: Removing Stubborn Thigh Fat

  1. Hi Tim,

    Near the end of the Occam’s to-failure sets, I experience a strong pain in my head with every heartbeat which makes it very difficult to proceed to muscular failure. I am an experienced trainer and know my limits – so I would stop if it was truly getting dangerous – and I am wondering how you recommend breathing during these sets. The normal inhale during negative, exhale during positive does not quite work given the slow cadence.

    Love the book, thanks,


    • Hi Jon,

      I would definitely see a doctor if this continues, ideally even before your next session. With the 5/5 cadence, you’ll be taking multiple breaths on the raising and lowering of the weight. Breath normally “behind the shield” (braced abs, google “Pavel” and this term) and don’t contort the face or ever hold breath.




      • Hi Tim , check out AOD9064. A fragment of Hgh that reduces fat without any side effects. Australian Coy. Called PHOSPHAGENICS. Will be selling a cream the can be rubbed onto problem areas with AOD9064 in it. This HGH has been Phosphahyalorised and goes straight thru the skin and melt Subcutaneous Fat, If you need to know more contact me at …

        Loved your new audio book.

        cheers pigofsteel.


      • body shape is surprisingly little due to food, nutrition or creams. What doctors and research couldn’t find in the last 50 years, you guys seem to really want to find. Go for it!

        But I might say you look in the wrong direction. You might want to turn 180 degrees and look at HOW you move (e.g. with the Feldenkrais Method, which Tim mentions in 4HB). Also “glued together” fascia is key in researching this.

        I find we humans are the only species who can do bodywork and massage etc each other. Maybe a simple, loving massage would have saved this girl’s hand another operation …

        and Jon the headache …


      • Interesting comment about humans being the “only species who can do bodywork and massage etc each other”…I watch my horses scratch and “massage” each other on a daily basis, and chimps and even cats do the same. I’d be willing to bet than any social species engages in some sort of grooming, massage, or bodywork…which probably goes to show that it is a necessary and useful tool in one way or another.


    • i have this problem also. (i’ve always been headache prone, doctors never found anything).
      what helps me is:
      1: focus on the muscles you are working on. sometimes other muscles are being tensed too much unnecessarily (neck?).
      2: keep your mouth open.


    • It sounds like some people are experiencing EIH–Exercise Induced Headaches. It seems to be a common problem in slow motion strength training. From what I understand, the exact cause isn’t known, but I have seen it more frequently when the person exercising starts to hold their breath or breathes “high” while also tensing the shoulders. It’s as if the effort comes from the head and shoulders, rather than the muscles that should be working. Proper form and breathing should help.

      The *instant* a headache starts, it’s best to stop the exercise, take a small break, drink a lot of water, maybe try a few neck exercises, then go to a different, less EIH-likely exercise before attempting that exercise again. Definitely see a doctor if the problem persists or is extreme. *Don’t* workout, at all, through a headache. The two most common exercises I’ve seen bring on EIH are the Leg Press and Chest Press.

      I apologize if I’m off-base. One of my certifications is in Super Slow Strength Training, and EIH is an important part of of the certification training and things we watch out for. I haven’t had a client experience it fully firsthand, I like to think because I really push proper form, breathing, and paying attention to how an exercise feels.

      I hope you stop getting the headaches!


    • Hi Jon,
      I’m not Tim, a doctor, or a trainer just a young gym rat who had the same thing. For me it turned out to be a pulled/strained muscle in my neck, possibly the trap. My chiropractor did acupuncture and all was well in 2 sessions


    • Or more women could start doing heavy deadlifts & squats – in the 1x body weight range and higher and then learn to love having “soccer player” legs. They’re good for more than just playing soccer ;)


  2. Thank you!! The only place my body wants to store fat is on my abs..very frustrating to say the least. I can’t wait to try this! You rock Tim! Thanks for doing all the dirty work.


  3. Hi Tim,

    This is semi related, but until the forum opens up I can’t think of a better place to ask a question.

    High estrogen in men. What can one do to combat it?


    • Hi Astroboy,

      Here are a few ideas:

      Minimize phyto- and xenoestrogens –
      – Limit soy intake
      – Limit marijuana intake

      In all cases, I would have comprehensive blood testing done to determine if your HPTA axis (just ask them or google it) is out of whack for some reason.

      Good luck!



      • I’ve heard good stories about using ground flax seed. Potent anti-estrogenic effects. Also a good source of omega-3 fat, and anti-oxidants (lignans).

        I wouldn’t overdo it though.

        Another note: even though called “the female hormone”, estrogen is also naturally occuring in the male body, no need to completely eliminate it.


      • I would definitely stop all alcohol as well, especially beer as it is very estrogenic, thus the many men with beer boobs.


      • Personally, I foolishly used all three testosterone inhibitors–alcohol, marijuana, soy–all throughout puberty (although I was ignorant of soy’s side effects at the time). My brother, who used none of the three, is noticeably more masculine than I am in our early twenties.

        Is that all she wrote? I know Ferriss mentions that the cod liver reversed stunted growth in some animal testing…is it possible to chemically encourage growth and testosterone’s shaping effects into adulthood?

        “Americans’ anxieties can be summed up by too much email and getting fat” – Tim Ferriss

        …and yet, there’s a third. I’m curious if at any point you researched, how can I put it, increasing maleness?

        The assumption is that it’s unchangeable. By Ferriss’s process, to test that assumption, we’d have to look for outliers. Has anyone ever boosted their size? How did they do it? Is it repeatable?

        Tim, spot reduction is a holy grail for some of your readers, I’m sure. But for many Americans, it calls to question: what about spot enhancement?

        Thanks for your replies.


    • An enzyme called aromatase, located in estrogen-producing cells in the adrenal glands testicles, adipose tissue,or fat around the belly, converts testosterone into estrogen. So the older you are and the fatter, the less “Mr The endocrine system must be looked at as a whole.


    • Please check out button mushrooms, the only source of naturally occurring aromatase inhibitors. There are several stages at which you can influence the level of testosterone and estrogen in your body.

      – production: directly dependent on level of monosaturated fats in the blood. nuts are a good source. walnut and almonds are particularly good as they contain other important minerals too

      – conversion: high amounts of testosterone will be converted to estrogen by enzyme aromatase. natural food ligans (soy) will boost aromatase as well as provide the raw material for estrogen. alcohol jacks up aromatase levels significantly. *button mushrooms* on the other hand, are the only known source of aromatase inhibitors (isolated compounds currently undergoing trials as a breast cancer treatment, google “aromatase inhibitor” to find out more). the reason why you are seeing excess of estrogen is probably due to both high estrogen production and high conversion. you can block both by avoiding estrogenic foods like soy and regularly including button mushrooms in your diet (100gms a day is the threshold for seeing some effects, i have used 200gms a day quite regularly). avoid alcohol if you can.

      – binding: about 98% of the testosterone in your blood stream is bound by SHBG and is useless. there are no known safe substances countering SHBG, but an Indian ayurvedic remedy known as shilajit probably works. caution: no established standard of purity and some samples may contain heavy metals. use at your own risk. 2 grams a day is the max dose you can go for, more than that is risky.

      a three day experiment is good enough to know whether it is working or not. you should see an immediate impact on libido as testosterone levels rise.

      as a side note, garlic worked for me initially, but subsequent experiments were inconclusive as the outcome swung both ways, making it a wildcard.





  4. I think both links take me to the same page. Interesting, i could use some help on my love handles. But i rather prefer to start doing the kettlebell swing and the cat vomit first and, if results are not noticeable, then i’ll try this


  5. Tim,

    I got my copy of The Four Hour Body and have started my kettle bell training. Did the before measurements and photos, so I am curious to see the results. I am scheduling a switch to the bench press increase regimen in April, as this has been a weak spot of mine as well.

    My hope is that I get rippe enough to put a photo of me in Flipside Erotica: Both Sides of the Story Vol. 2 which is due out this spring. Barnes & Noble is reviewing Vol. 1 as we speak, and when (not if) I get on the shelves I am going to owe you big time! I have followed your advice on marketing and PR, and your ideas have really worked for me. I can’t thank you enough. I just landed a spot on Playboy radio!!!

    All the best,

    Darren Michaels
    Independent Publisher Award Winner–2010
    Flipside-Erotica: Both Sides of the Story


  6. Tim,

    I almost forgot…I spoke to Nina Hartley recently. She is going to do an endorsement for my book!

    My blog is coming along nicely; I am sure that Tucker Max would never bother to return an email from me, so if you see him, tell him I said thanks for the path to follow.




  7. I ordered this using the affiliate link. Consider the modest commission a thank you. I am 5′-9″ and 130 pounds; not fat at all, but my thighs are kinda lumpy. Whenever I’ve lost enough weight to smooth them out, the rest of me looks emaciated. If I could have thin thighs without having clavicles that could puncture a tire – well, that would be wonderful.


    • hey Lisa, your post just made me actually L.O.L. I’m sorry. I have the same problem!! I can get those thighs lean, but then the rest of me looks like a zombie! Keen to test out this cream and the training methods Tim. thanks for your experimentation..


  8. Hey Tim,

    I just got my copy of the 4-Hour Body and I’ve been glued to it since arrival. Few questions (since there is no forum yet)… Is there such a thing as too low body fat for women? From the book’s picture reference, I’m somewhere in the 7-9% range and I haven’t had a period for over a year and a half, which isn’t healthy or normal and every doctor I’ve been dragged to see has told me that it’s related to low body weight (I’m 60.5″ and somewhere around 96 lbs) and not enough body fat. Any thoughts? Also, as a college student, what would you suggest for trying to modify some of the diets, since dining halls don’t tend to have spinach and beans for breakfast?


    • Hi Teresa,
      I work with women on fertility a lot, and this question comes up often. Most women need to be at least 12-15% body fat for optimal fertility and hormone function, though there are exceptions to this. Things like overtraining, extreme calorie restriction or toxin exposure can also contribute to the problem. I usually recommend to women that they cut out grains and refined foods of all kinds and make sure they are eating a lot of healthy fats from good sources like clean meats, coconut, avocado, butter, olive oil, olives, and nuts (soaked). Often, this alone can help bring back a cycle. If not, other dietary changes and certain supplements will help. In college, I kept avocados, olives, nuts and coconut oil in my dorm. I would eat an omelet for breakfast, salad with protein for lunch and some kind of stir fry for dinner. In my room, I would snack on the avocados, olives and nuts or add coconut oil to coffee or tea (texture is a little rough, but it floats, so it is only in the first sip or two). The coconut oil also has great medium chain fatty acids and is great for your thyroid, hair, and skin.
      I hope this helps some. There is more nutrition info on my site, or feel free to contact me directly on my contact form if I can help.


      • Can I get your site link please? I am interested in what I read on your post on the 4 hour work week. Thanks


    • Hi Teresa,
      I agree with Katie regarding the type of diet you should follow. As someone who has trained a lot, at one point I had a bodyfat of less than 14% which is generally considered quite athletic for a woman. Less than 12% is definitely _not_ recommended and, as far as I know, dropping to 10% or below can prevent you from having kids… even if you are not thinking about having any right now, that’s only one more reason to watch out with that amenorrhea.
      That having been said, you also mentioned you are a college student? If you are under a lot of stress this might be another factor to consider (especially if you’ve had a very low bodyfat % for a long time).


  9. Hi! This isn’t necessarily related to this post but I didn’t know where else to ask :) I’ve been reading the 4HB and had a few questions. Is there any sort of protein shake formula that you recommend that is low in carbs and sugar that would be alright to consume on the Slow Carb Diet? Secondly, do you know anything about Sugar Alcohols – seems to be a new marketing tactic that people are using to label chemicals lol, but do you know what affects this has on blood sugar levels? Lastly, not sure if you’ve tried any Ganoderma Lucidum supplements before but I’ve heard they can help reduce spikes in blood sugar – any insight regarding this? Thanks so much!!!


    • Gotta run to a plane, but I would:

      – Consider unflavored whey protein with cold water for SCD
      – Avoid sugar alcohols for many reasons

      I’m not familiar with the supps you mentioned.




    • As for high-protein, low-carb shakes, my friends and I have been using Optimum Nutrition Gold Standard Whey Protein for many years, that’s our favorite.

      I recently also started using Primal Fuel, which has high quality ingredients and in addition to the protein it has a higher amount of carbs and coconut fats. So it’s more of a meal replacement than a protein shake.

      I recommend both.


    • Rachel,

      I know this comes to you months later but I have been loving Pure Protein Shake (Frosty Chocolate). It has 35 grams of protein, 4 grams of carbs, 1 gram of fat. I drink one of these every morning.


  10. Hi Tim!
    Love the book!
    “Ate” it up in one weekend sitting -opposite of your directions.

    Any suggestions on how to incorporate lentils in the diet if you abhor lentils. I find the texture/taste and not sure how to cook to make them good out of the can.. usable.

    Suggestions would be incredibly helpful!


      • Recently found vac-packed steamed organic lentils at Trader Joe’s. At $3 for a 5-serving packet, it’s expensive compared to the cost of bulk lentils, which are totally dirt cheap. But these are well-worth the cost for convenience. They are perfectly prepared, simple and ready instantly, hot or cold. There’s also no need to sift through for little stones. This packaging put lentils on my daily menu.


    • Be aware that some people have an adverse reaction to lentils. If your joints start getting stiff, like you’ve suddenly developed arthritis, you’re probably one of those people. So keep track of how you’re feeling once you start adding lentils to your diet.


      • Huh, I’ve been having pain in my hip since I upped the lentils. Pretty severe sometimes. Rats! I love lentils. Anyone know why this happens?


    • That’s how I do it and it’s yum!

      1 can of brown lentils. Washed and drained.
      1/2 Onion, chopped finely
      Parsley, chopped. (quantity to taste, I usually have a handful of it)
      Olive oil (to taste)
      Balsamic vinegar (to taste, but a good proportion is one volume of vinegar for 3 to 4 volumes of olive oil depending on how sour you want it)
      salt and pepper to taste

      Mix everything up and enjoy cold like a salad.

      Total cooking time, 5mn.

      Great with a side of eggs for breakfast or simply as a side on other meals.


      • Drat! I’ve looked about for more lentil loaf recipes but most of them use some kind of crumb/starch to bind things. In my heavy-duty Atkins days we’d use porkrinds in the food processor as a substitute for breadcrumbs (it’s *fabulous* on chicken), but it seems almost wrong to put pork in a lentil loaf. Thinking about experimenting with some dessicated coconut flakes put through the food processor.

        Speaking of coconut, I also have an interesting recipe for coconut bacon I came across:

        3 large handfuls of bulk coconut
        1 tablespoon liquid smoke
        2 tablespoons soy sauce/ tamari
        1 tablespoon water
        1 tablespoon maple syrup (optional)

        Less for the bacon replacement, and more to get those medium-chain fatty acids into my diet more regularly. I know the maple syrup is out, but any issues with tamari or liquid smoke?


    • You could try cooking from scratch french green lentils (only about 20 minutes), they hold their shape and have a nicer texture than brown lentils.


  11. Ok, Tim. I bought some cream. Questions: Can I apply this to other fatty areas of the body i.e., the bicep area? Would you consider twice a day for 18 days to be the correct dosage and then stop to observe the residual effect? As another poster brought up, where does this fat go?

    Thank you!


    • Tiffany, as to where the fat goes, I”m not 100% clear on the mechanism off-hand, but my guess is that it’s broken down into triglycerides/FFAs and transported to the liver, where it’s processed. Perhaps someone in the comments better at off-the-cuff mo-bio could help elaborate?


      • There are lot of different pathways for a triglyceride to be used. All in all, the triglyceride molecule consist of 1 glycerol molecule and 3 fatty acids, which are chained together. When it is released into the bloodstream it is broken down to glycerol and free fatty acids. Glycerol is mainly converted into glucose, which is converted to 2 pyruvate molecules and used as fuel to create ATP in the mitochondria. Free fatty acids has MANY pathways. When it hits the bloodstream it can be processed in the liver, muscle and many other places. In the musclecells it is mainly being used as fuel, it is transported into the mitochondria and used to create ATP in the mitochondria. In the liver it can be used to create cell-membrane compounds, other forms of fat-molecules and a lot of other stuff. Hope that was biochemical enough :)


    • Tiffany, if the active ingredient’s charm is that it works on A2 receptors than slapping it on your bicep is a bit of a waste. You wanna put it on areas that are hard to mobilize, and that’s when you’re already reaching a certain level of leanness. For example, I wouldn’t bother with it if I was a male and 15% bodyfat. That’s too high.

      The free fatty acids hit your blood stream. That’s why it’s imperative to be on a caloric deficit, or the fat will just go somewhere else eventually.


      • Tim and Brian,

        Thanks guys, you are awesome! I’ve been on a diet plan for awhile and I am losing, which is great but there are those stubborn areas :)

        My CelluThin has arrived and I’m ready to get started!


  12. Tim,
    Just bought your book today and already immediately implementing the strategies … your book is even beyond my expectations which were already very high.
    just curious if you knew about or tested Yohimburn ES, another A2 receptor antagonist and compared it to Celluthin. It’s even more pricey at $59 for 4oz spray, and i can tell you the spray bottle is designed badly because the liquid comes out in a stream and runs down your leg and invariably too much comes out per pump.
    I used it briefly but was so dismayed by the application of it, i didn’t finish or measure the results.
    Would love to know your opinion or if you used it??


  13. Hi Tim! Just downloaded your book to my e-reader,and I’m totally hooked. Just wanted to say thank you for the ridiculous amount of information you share! I’m a mom of 2 boys ages 5 and 3 and what I want more than anything is to be in the best shape possible to gain my sexy back, and be gorgeous arm candy for my hubby who’s a Chief in the Navy!

    So no questions, but just Huge Big Enormous Thank You!


  14. Well, it blows me away to hear that something like Celluthin might actually work. Just goes to show you, if something sounds too good to be true…well, it probably is, but it’s still worth checking out.


  15. Thanks for another great book Tim….love your stuff. Quick question regarding stubborn thigh fat…any specific exercises that you would recommend to try and trim away that stubborn thigh upper body is slim and tone, but my thighs just will not budge…

    Thanks again!